Wheelchair handball has been popular in South and Central America over the past two decades and has getting more and more focus in the region. While Brazil has been the driving force, other nations have adopted the discipline as well, such as Chile.

In Brazil, wheelchair handball made its debut in 2005, in the city of Toledo, Paraná. Professor Décio Roberto Calegari and his collaborators developed the rules for the practice of handball in a wheelchair, trying to create a dynamic, inclusive and low-cost sport, which culminated in the creation of Wheelchair Handball Four-a-Side.